Sitemeter tells me that today, especially late morning and early afternoon, a lot of people were searching for the difference between Penn State and the University of Pennsylvania. U Penn is the ivy league school. Penn State is state -related, U Penn is private. Or something like that. Websites: www.psu.edu and www.upenn.edu. Oddly enough Penn State is not the state university for Pennsylvania. Penn State is the school a lot of our elected officials attended, U Penn is where a lot of their children go. Penn State is the one currently in the news and not for happy reasons.